Increase in Aβ production is followed by chelation of transition metal ions by Aβ, accumulation of Aβ-metal lipoprotein aggregates, production of reactive oxygen species and neurotoxicity. Chelation of copper by Aβ is proposed to be a most important part of this pathway, because Aβ binds ds 7616ni e2 16p pdf stronger than other transition metals and because copper is a more efficient catalyst of oxidation than other metals. Aβ peptide from its central place in our current thinking of AD, but rather places additional factors in the center of discussion. Check if you have access through your login credentials or your institution.
The formulation of these problems is in terms of random walks inside polygonal domains in a two-dimensional lattice space with several reflecting barriers and one absorbing barrier. For the two-stacks problem, the return time to the origin, the time to absorption, the last leaving time from the origin and the number of returns to the origin before absorption are investigated. For the banker’s algorithm, the trend-free absorbed random walk is analysed with numerical methods. We finally analyse the average excursion along one axis for the classical random walk: an analytic method enables us to deduce asymptotic results for this average excursion. This work was supported in part by the PRC Mathématiques et Informatique.
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